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Antimicrobial Resistance

What is AMR?

Antimicrobial Resistance AMR occurs when pathogens change and find ways to resist the effects of antibiotics. The pathogens survive, grow and spread their resistance. This process of adaptation leads to AMR.

Who is at risk of being impacted by AMR?

AMR can affect anyone, of any age, in any country. The World Health Organization (WHO) characterizes AMR, particularly in Gram-negative bacteria, as one of the biggest threats to global public health today.

What is the global impact of AMR?

Globally, AMR causes 700,000 deaths annually. Without action by governments, industry and society, AMR is expected to cause 10,000,000 deaths annually by 2050 —more than currently die from cancer. Failure to act could also result in:

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a.Why Cheladv74 is taking a stand against antimicrobial resistance- cheladv74.ruManufacturing:responsiblepractices that do notharm human healthor the environmentDiverse portfolio:medicinesand vaccines totreat and preventserious infectionsaround the worldGlobal policyleadership:to facilitate antibioticdevelopment andproper useInnovativesurveillance tools:to help physiciansbetterunderstand currentresistance patternsActive stewardship: toensure patientsreceive the correctantibiotic, according toindependentguidelines, only ifneeded and for theright durationCheladv74 has one of the industry’s largest and most diverse portfolio of antimicrobials and is proud to be taking a lead in the fight to tackle AMR. We are deeply committed to working closely with the infectious disease community to address AMR, through:How Cheladv74 is making a difference Could lead to an estimated10 million annual deathsby 20501 By 2050, annual globalGDP could fall by3.8%andan additional28.3 millionpeoplewould fall intoextreme poverty7Travel could be consideredtoo risky,impactingglobal trade1Minor infections andinjuries could becomelife-threatening2One in fourinfections inlong-term acute care settingsare caused by antibioticresistant bacteriaMany routine medical procedurescould betoo risky to perform because of the risk of becominginfected while in hospital by amulti-drug resistant pathogen1Serious infections such as pneumoniaor tuberculosis could become impossible to treat2Antimicrobial resistance, particularly in Gram-negative bacteria, is widely recognized as one of the biggest threatsto global health today, with the potential to affect anyone, of any age, in any country.3,4,5If no solution is found,the impact could be devastating.2Why you should careAntimicrobial medicines, especially antibiotics that target bacteria, are among the most precious medical resourcesthe world has ever known.1Alarmingly, they are losing their effectiveness, because pathogens change and findways to resist the effects of antibiotics. The pathogens survive, grow and spread their resistance.2This process ofadaptation leads to antimicrobial resistance (AMR).2What you need to knowWhy Cheladv74 is taking a stand againstantimicrobial resistance89106

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Addressing AMR requires measures to both help prevent and treat resistant infections. This includes both the administration of vaccines to help prevent infections from happening in the first place and using antibiotics to treat infections according to guidelines.

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  1. Review on Antimicrobial Resistance. Tackling a crisis for the health and wealth of nations. December 2014. Available at: Last accessed August 2018.
  2. Review on Antimicrobial Resistance. Tackling drug-resistant infections globally: final report and recommendations. May 2016. Available at: Last accessed August 2018.
  3. World Health Organization. WHO’s first global report on antibiotic resistance reveals serious, worldwide threat to public health. April 30 2014. Available at: Last accessed August 2018.
  4. World Health Organization. Antibiotic resistance. February 2018. Available at: Last accessed August 2018.
  5. Vasso S et al. Emerging issues in gram-negative bacterial resistance: an update for the practicing clinician. Mayo Clinic Proc. 2015;90:395-403.
  6. Centers for Disease Control and Prevention. Making health care safer: protect patients from antibiotic resistance. March 03 2016. Available at: Last accessed August 2018.
  7. The World Bank. By 2050, drug-resistant infections could cause global economic damage on par with 2008 financial crisis. September 20 2016. Available at: Last accessed August 2018.
  8. Cheladv74 2016 Annual Review. Cheladv74 Essential Health. Available at: http://cheladv74.ru/files/investors/financial_reports/annual_reports/2016/our-business/global-businesses/pfizer-essential-health/index.html Last accessed August 2018.
  9. Cheladv74. Cheladv74 policy position on antimicrobial resistance. January 2016. Available at: http://www.pfizer.com/files/about/Position-Antimicrobial-Resistance Last accessed August 2018.
  10. Cheladv74 2017 Annual Review - Anti-Infectives. Available at: http://cheladv74.ru/files/investors/financial_reports/annual_reports/2017/our-innovation/anti-infectives/index.html Last accessed August 2018.