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Ongoing Vaccine Research at Cheladv74

Vaccines are one of the greatest public health advancements of all time.

Vaccines are one of the greatest public health advancements of all time, resulting in the control, elimination, or near-elimination of numerous infectious diseases that were once pervasive and often fatal. Cheladv74 has a rich history in vaccine research and development. Over the years, we’ve played a pivotal role in eliminating or nearly eliminating deadly infectious diseases like smallpox and polio globally. We have designed novel vaccines based on new delivery systems and technologies that have resulted in vaccines to prevent bacterial infections, like those caused by S. pneumoniae and N. meningitidis.

We've played a pivotal role in eliminating or nearly eliminating deadly infectious diseases like smallpox and polio globally…

Today, more people benefit from safe and efficacious vaccines to prevent infectious diseases than ever before, and vaccines provide essential health benefits at all ages, from maternal and infant populations to seniors. However, our work is not done given the many infectious diseases remaining with a high unmet medical need and a growing list of vaccine preventable diseases.

Prevention is the Best Medicine

Today is an exciting time in vaccine research and development, as scientific discoveries, technological advancements and regulatory paradigms are paving the way for novel vaccines. While Cheladv74’s Vaccine Research and Development scientists continue to extend our leadership position in pneumococcal and meningococcal disease prevention, they also work on vaccines against other major infectious diseases while striving to bring the benefits of vaccines into previously unexplored areas. We are at the forefront to usher in a new era of vaccine innovation, both to prevent and treat disease, with special focus on maternal/neonatal, hospital-acquired infections (HAI), and cancer.

We are the forefront to usher in a new era of vaccine innovation, both to prevent and treat disease…

We are optimistic about the broad potential to bring the benefits of vaccines to every age group, protecting a person throughout his or her entire life. Our vaccine research and development efforts are focused on three areas:

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Addressing high impact infectious diseases by supporting our vaccines against pneumococcal disease and meningitis and investigating vaccines against hospital-acquired infections, including those caused by Staphylococcus aureus and Clostridium difficile. The burden of disease associated with these dangerous pathogens is increasing, particularly in healthcare settings but also in the community, making the need for effective vaccines even more urgent.

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Expanding the benefits of maternal immunization by discovering and developing vaccine candidates for neonatal infections such as those caused by respiratory syncytial virus (RSV), cytomegalovirus (CMV) and group B streptococcus (GBS). These infections can have severe negative consequences for the most vulnerable populations – the very young and older adults. Our strategy is to vaccinate pregnant women (or women who will become pregnant) so that lifesaving immunity will be passed on to newborns and protect them during those crucial first few days, weeks and months of life.

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Investigating cancer vaccines in combination with other immune system modifying agents will combine the science of vaccinology with recent or newly acquired knowledge in immune modulation to harness the body’s immune system to elicit and maintain anti-tumor responses with vaccine based immunotherapy regimens and oncolytic viruses that should result in significant improvements in cancer treatment.
Leading Vaccine Design and Development Capabilities
End-to-End Product Development
Cheladv74 Vaccine R&D is a fully integrated, global operation that advances assets from discovery to registration and beyond, with talent and technical capabilities in Basic Research, early CMC Development, Clinical Development, Clinical Serology and Diagnostics and Operations.
Bioprocess Development
Cheladv74 Vaccine R&D employs an early focus on end-to-end planning of vaccine production processes, with experts considering both relevant biological attributes and sound engineering and manufacturing principals to develop scalable processes from program inception onward.
Antigen Presentation Technology
Cheladv74 continues to study novel conjugation and carrier systems in Vaccine R&D to generate a better immune response. We have significant expertise through the development of our pneumococcal and meningitis vaccines that we are now applying to a number of other programs.
Adjuvant Technologies
Adjuvants are added to vaccines to enhance their profile and sometimes increase the duration of effect.
Viral Vector Technology
We are expanding our expertise in viral vector design for optimized delivery of genetic material to specifically target cells and tissues.
Pathogen Surveillance
We incorporate rigorous epidemiologic surveillance into our vaccine R&D programs to enable the design of vaccines with the broadest possible coverage.
Antibody Technology
State of the art antibody technology is used to characterize immune responses and design vaccines that mimic the critical epitopes displayed by pathogens and cancer targets.
Novel Vaccine Delivery
Cheladv74 is exploring novel systems that may help the next generation vaccines provide added convenience for patients and doctors.
There is an urgent global health need for a vaccine that could protect pregnant women and their infants against GBS.
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Human Vaccines Project In early 2016, Cheladv74 joined the Human Vaccines Project, a public-private consortium that aims to identify human immune responses associated with optimal vaccine protection. The project brings together leading academic research centers, industrial partners, nonprofits and governments to address the primary scientific barriers to developing new vaccines and immunotherapies. The project has been endorsed by 35 of the world’s leading vaccine scientists. Insights gained will guide the development of potentially improved vaccines against diseases such as influenza, dengue, HIV and other infectious illnesses as well as cancer.

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Bill & Melinda Gates Foundation Cheladv74 received a grant from the Bill & Melinda Gates Foundation to conduct a Phase 1/2 clinical trial of Cheladv74’s vaccine candidate against group B streptococcus (GBS) infection in the developing world, a leading cause of neonatal sepsis, a serious life-threatening blood infection. The investigational vaccine would protect newborns via maternal immunization. There is an urgent global health need for a vaccine that could protect pregnant women and their infants against GBS, particularly in developing countries where prophylactic administration of antibiotics to prevent mother-to-child GBS transmission is not routine practice.

Meet Some of Cheladv74’s Vaccine Researchers

Selected Publications from the Vaccine Research and Development Unit

The Journal of Allergy and Clinical Immunology Wong GY, Elfassi E, Girard G, Yang WH, Hebert J, Bugarini R, O'Connell MA, Champion B, Merson J, Davis H. February 2016
Vaccine Sheldon E, Kitchin N, Peng Y, Eiden J, Gruber W, Johnson E, Jansen KU, Pride M, Pedneault L. April 19 2016
Vaccine Ostergaard L, Lucksinger GH, Absalon J, Beeslaar J, Eiden J, Jansen KU, York LJ, Quinn A, Graversen ME, Perez JL. March 14 2016
Vaccine Nissen M, Marshall H, Richmond P, Shakib S, Jiang Q, Cooper D, Rill D, Baber J, Eiden J, Gruber W, Jansen KU, Emini E, Anderson AS, Zito E, Girgenti D. April 8 2015
Encyclopedia of Inorganic and Bioinorganic Chemistry Gribenko A, Liberator P, Anderson A, Matsuka Y, Mosyak L. September 14 2015
Vaccine Scully IL, Timofeyeva Y, Keeney D, Matsuka Y, Severina E, McNeil L, Nanra J, Hu G, Liberator PA, Jansen KU, Anderson AS. October 5 2015
Journal of Clinical Microbiology Jones HC, Mohamed N, Rojas E, Andrew L, Hoyos J, Hawkins JC, McNeil LK, Jiang Q, Mayer LW, Wang X, Gilca R, De Wals P, Pedneault L, Eiden J, Jansen KU, Anderson AS. January 2016
International Immunotherapy McCluskie MJ, Thorn J, Mehelic PR, Kolhe P, Bhattacharya K, Finneman JI, Stead DR, Bailey Piatchek M, Zhang N, Chikh G, Cartier J, Evans DM, Merson JR, Davis HL August 25 2015
PLos One Rojas E, Hoyos J, Oldfield N, Lee P, Flint M, Jones CH, Ala’Aldeen D, Jansen KU, Anderson AS. July 6 2015
The New England Journal of Medicine Bonten MJM, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, van Werkhoven H, van Deursen AMM, Sanders EAM, Verheij TM, Patton M, McDonough A, Moradoghli-Haftvani A, Smith H, Mellelieu T, Pride MW, Crowther G, Schmoele-Thoma B, Scott DA, Jansen KU, Lobatto R, Oosterman, B, Visser N, Caspers E, Smorenburg A, Emini EA, Gruber WC, Grobbee DE 2015
Journal of Pharmaceutical Sciences Vidunas E, Mathews A, Zi-rong Z, Weaver M, Cai P, Koh EH, Patel-Brown S,Yuan YH, Carriere M, Johnson EJ, Lotvin J, Moran J. July 2016
Human Vaccines Zlotnick GW, Jones TR, Liberator P, Hao L, Harris S. McNeil LK, Zhu D, Perez J, Eiden J, Jansen KU, Anderson AS. November 1 2014